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Inhibition of histone deacetylases (HDACs) has been implicated to modulate transcription and to
 induce apoptosis or differentiation in cancer cells. The HDAC Fluorometric and Colorimetric Assay Kits provide simple procedures for fast and convenient measurement of HDAC activity by fluorometric and colorimetric methods. The methods eliminate radioactivity, extractions, or chromatography, as used in the traditional assays. The new procedures require only two easy steps, both performed on the same microtiter plate. First, the HDAC fluorometric (or colorimetric) substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity (e.g., HeLa nuclear extract). Deacetylation sensitizes the substrate, and thus in the second step, treatment with the Lysine Developer produces a fluorophore (or chromophore), which can be analyzed using a fluorometric (or colorimetric) plate reader. The HDAC Inhibitor Drug Screening Kit provides sufficient positive controls for screening 100 samples of HDAC inhibitor candidates in drug discovery. HDAC inhibitors and antibodies are also available separately. |
| HDAC Kits | Cat. # | Size | Price (USD) | Data Sheet  |
Add to Cart
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| HDAC Fluorometric Assay Kit | K330-100 | 100 assays | $295.00 | Product Data Sheet |  |
| HDAC Colorimetric Assay Kit | K331-100 | 100 assays | $295.00 | Product Data Sheet | |
| HDAC Inhibitor Drug Screening Kit | K340-100 | 100 assays | $395.00 | Product Data Sheet | |
| HDAC Enzymes | Cat. # | Size | Price (USD) | Data Sheet |
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| HeLa Nuclear Extract | 1641-01 | 100 ug | $95.00 | Product Data Sheet | |
| HeLa Nuclear Extract | 1641-1 | 1 mg | $255.00 | Product Data Sheet | |
| Recombinant HAT Protein | 1137-100 | 100 ug | $265.00 | Product Data Sheet | |
| HDAC Inhibitors | Cat. # | Size | Price (USD) | Data Sheet |
Add to Cart
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| Apicidin | 1601-1 | 1 mg | $105.00 | Product Data Sheet | |
| M344 | 1607-1 | 1 mg | $105.00 | Product Data Sheet | |
| Trichostatin A | 1606-1 | 1 mg | $135.00 | Product Data Sheet | |
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