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Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin protease may intiate or propagate proapoptotic signals, but it is currently unclear how cathepsin mediate apoptosis. Cathepsin are lysosomal enzymes that are also used as sensitive markers in various toxicological investigations. BioVision's newly developed Cathepsin Activity Assay kits are fluorescence-based assays that utilize the preferred substrate sequence for each cathepsin, labeled with AFC (amino-4-trifluoromethyl coumarin). Cell lysates or other samples that contain cathepsins will cleave the synthetic substrate to release free AFC. The released free AFC can easily be quantified using a fluorometer of fluorescence plate reaser. The cathepsin assays are simple, straightforward, and can be adapted to 96-well plate assays. Assay conditons have been optimized to obtain the maximal activity. Active cathepsin and cathepsin inhibitors are also available.
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| Cathepsin Assay Kits | Cat. # | Size | Price (USD) | Data Sheet  |
Add to Cart |
| Cathepsin B Activity Assaay Kit | K140-100 | 100 assays | $295.00 | Product Data Sheet |  |
| Cathepsin D Activity Assay Kit | K143-100 | 100 assays | $295.00 | Product Data Sheet | |
| Cathepsin K Activity Assaay Kit | K141-100 | 100 assays | $295.00 | Product Data Sheet | |
| Cathepsin H Activity Assay Kit | K145-100 | 100 assays | $295.00 | Product Data Sheet | |
| Cathepsin L Activity Assaay Kit | K142-100 | 100 assays | $295.00 | Product Data Sheet | |
| Cathepsin S Activity Assaay Kit | K144-100 | 100 assays | $295.00 | Product Data Sheet | |
| Cathepsin Protein | Cat. # | Size | Price (USD) | Data Sheet |
Add to Cart |
| Cathepsin B (Active) | 1021-5 | 5 ug | $115.00 | Product Data Sheet | |
| Cathepsin D (Active) | 1022-5 | 5 ug | $115.00 | Product Data Sheet | |
| Cathepsin H (Active) | 1023-5 | 5 ug | $115.00 | Product Data Sheet | |
| Cathepsin L (Active) | 1135-5 | 5 ug | $95.00 | Product Data Sheet | |
| Cathepsin L (Active) | 1135-100 | 100 ug | $295.00 | Product Data Sheet | |
| Cathepsin L (Active) | 1135-1000 | 1 mg | $2650.00 | Product Data Sheet | |
| Cathepsin S (Active) | 1025-5 | 5 ug | $115.00 | Product Data Sheet | |
| Cathepsin Inhibitor | Cat. # | Size | Price (USD) | Data Sheet |
Add to Cart |
| Cathepsin B&L Inhibitor, Z-Phe-Phe-FMK | 1126-20C | 20 ul | $155.00 | Product Data Sheet | |
| Antibody to | Cat. # | Host | Species | Application | Size | Price (USD) | Data Sheet |
Add to Cart |
| Cathepsin B | 3190-100 | Rb | hu | WB/IHC | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin D | 3191-100 | Rb | hu | WB/IHC | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin F | 3371-100 | Rb | hu/ms | WB | 100 ul | $245.00 | Product Data Sheet | |
| Cathepsin G | 3370-200 | Rb | hu | WB | 200 ul | $245.00 | Product Data Sheet | |
| Cathepsin H | 3367-100 | Gt | hu/ms/rt | WB | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin K | 3588-100 | Rb | hu/ms/rt | WB/IP/IHC | 100 ug | $195.00 | Product Data Sheet | |
| Cathepsin L | 3230-100 | Ms | hu | WB/IHC | 100 ug | $265.00 | Product Data Sheet | |
| Cathepsin L | 3192-100 | Rb | hu | WB | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin L (Cleaved) | 3741-100 | Rb | hu/ms/rt | WB | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin P | 3369-200 | Rb | hu | WB | 200 ul | $245.00 | Product Data Sheet | |
| Cathepsin S | 3366R-100 | Rb | hu | WB | 100 ug | $195.00 | Product Data Sheet | |
| Cathepsin S | 3366-100 | Gt | hu/ms/rt | WB/IP/IHC | 100 ug | $225.00 | Product Data Sheet | |
| Cathepsin V | 3411-100 | Ms | hu | WB/IHC | 100 ug | $285.00 | Product Data Sheet | |
| Cathepsin V | 3712-100 | Rb | hu/ms/rt | WB | 100 ug | $235.00 | Product Data Sheet | |
| Cathepsin W | 3412-100 | Ms | hu | WB/IHC | 100 ug | $255.00 | Product Data Sheet | |
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| See Also... | ||||
| Calpain Activity Assay Kit & Reagents |
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