|
b-Secretase (BACE) is a membrane-bound aspartyl protease that cleaves the amyloid precursor protein to generate the N-terminus of the amyloid beta (ab) peptide. b-Secretase has been implicated to be an excellent target for anti-amyloid therapy for the treatment of Alzheimer’s disease. Finding inhibitors of b-secretase is one of the major goals of Alzheimer’s disease drug development. BioVision’s b-Secretase Fluorometric Assay Kit provides a convenient, nonradioactive system for detecting b-Secretase activity in biological and purified samples. The kit provides active b-secretase as the positive control, b-secretase inhibitor as the negative control, as well as the optimized substrate and buffers for convenient measurement of b-secretase activity in mammalian samples.
|