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TMP-195

A potent and selective class IIa HDAC inhibitor
Catalog #: B1860

Availability: In stock

SKU-Size Size Price Qty
B1860-5 5 mg
$125.00
B1860-25 25 mg
$495.00

Product Details

Alternate Name N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Appearance Crystalline solid
CAS # 1314891-22-9 
Molecular Formula C₂₃H₁₉F₃N₄O₃
Molecular Weight 456.42
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4
InChi InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)
InChi Key QTCSXAUJBQZZSN-UHFFFAOYSA-N
PubChem CID 67324851
Handling Protect from air and light
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors.
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