Tau-441, Human Recombinant

Microtubule-associated protein that promotes microtubule assembly and stability.
Part #: P1192

Availability: In stock

SKU-Size Size Price Qty
P1192-50 50 μg
$225.00
P1192-250 250 μg
$895.00

Product Details

Alternate Name MAPTL, MTBT1, TAU, Neurofibrillary tangle protein, Paired helical filament-tau
Gene Symbol MAPT
Gene ID 4137
Accession # P10636
Source E.coli
Appearance Lyophilized
Physical Form Description Freeze-dried in PBS
Molecular Weight 48 kDa
Purity by SDS-PAGE > 90%
Reconstitution Instructions Reconstitute to 4 mg/mL in sterile water.
Amino Acid Sequence MGSSHHHHHHSSGLVPRGSH - MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS R
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tau is a microtubule-associated protein involved in Alzheimer’s and Parkinson’s disease. It promotes microtubule assembly and stability, and might participate in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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