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Tanshinone IIA-Sulfonic Sodium

A potent ectosteric inhibitor of cathepsin K (CatK)
Catalog #: B1902

Availability: In stock

SKU-Size Size Price Qty
B1902-5 5 mg
$75.00
B1902-25 25 mg
$285.00

Product Details

Alternate Name Sodium tanshinone IIA sulfonate; Sulfotanshinone sodium II-A; T06
Appearance Off-white to orange red powder
CAS # 69659-80-9
Molecular Formula C₁₉H₁₇NaO₆S
Molecular Weight 396.39
Purity ≥98% by HPLC
Solubility DMSO or H₂O (~5 mg/ml)
SMILES CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+]
InChi InChI=1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1
InChi Key AZEZEAABTDXEHR-UHFFFAOYSA-M
PubChem CID 23669322
MDL Number MFCD09028094
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sodium tanshinone IIA sulphonate (T06) is a water-soluble derivative of tanshinone IIA, that displays versatile biological properties. Recently, it has been shown to act as an ectosteric inhibitor of cathepsin K (CatK). T06 binds in an ectosteric side of Cathepsin K remote from its active site and selectively inhibits collagen degradation. It also inhibits bone resorption in ovariectomized mice.


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