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Soluble Epoxide Hydrolase Inhibitor Screening Kit (Fluorometric)

Simplest High-Throughput Assay To Screen Soluble Epoxide Hydrolase Inhibitors
Catalog #: K480

Availability: In stock

$525.00

Product Details

Cat # +Size K480-100
Size 100 assays
Kit Summary • Detection method-Fluorescence (Ex/Em: 362/460 nm)
• Applications- Screening/studying/characterizing Soluble Epoxide Hydrolase inhibitors
Detection Method Fluorescence (Ex/Em: 362/460 nm)
Species Reactivity Human
Applications Screening/studying/characterizing soluble Epoxide Hydrolase inhibitors
Features & Benefits • Rapid, simple & sensitive
• Convenient & HTS
• Includes NCND (inhibitor control)
Kit Components • sEH Assay Buffer
• sEH Substrate
• NCND (5 mM)
• Human sEH Enzyme
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Soluble Epoxide Hydrolase (EC 3.3.2.10) is a cytosolic enzyme with highest expression in the liver but present ubiquitously in several organs including the kidney, pancreatic islets, pituitary gland, lymphoid tissues, muscles, and the gastrointestinal tract. It catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), i.e., epoxides derived from cytochrome P-450 mediated metabolism of arachidonic acid, to form vicinal diols. The EETs cause vasodilation and have anti-inflammatory actions. Since the EETs are hydrolyzed to diols through soluble epoxide hydrolase, the inhibition of this enzyme is likely to enhance the beneficial properties of EETs. This makes soluble epoxide hydrolase a very useful target for cardiovascular and pain medicine. BioVision’s Soluble Epoxide Hydrolase Inhibitor Screening Kit is a micro-plate based fluorometric kit for screening sEH inhibitors. Its assay principle is based on the hydrolysis of a non-fluorescent substrate to a fluorescent product by sEH. It uses N-Cyclohexyl-Nʹ-dodecylurea (NCND), a well-known sEH inhibitor, as positive control. The kit provides a simple and fast method to screen/ characterize potential sEH inhibitors.


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