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SL0101

A potent and selective inhibitor of ribosomal S6 kinase (RSK)
Catalog #: B1895

Availability: In stock

SKU-Size Size Price Qty
B1895-5 5 mg
$165.00
B1895-25 25 mg
$650.00

Product Details

Alternate Name 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
Appearance Yellow solid
CAS # 77307-50-7
Molecular Formula C₂₅H₂₄O₁₂
Molecular Weight 516.46
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)OC(=O)C)OC(=O)C
InChi InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1
InChi Key SXOZSDJHGMAEGZ-IGKKHSBFSA-N
PubChem CID 10459196
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SL0101 is a potent and selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not have any effect on upstream kinases such as MEK, Raf and PKC.  Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.


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