Shopping cart is empty
Phone: 408-493-1800 | Fax: 408-493-1801
 My Wish List | My Account | Checkout

My Shopping Cart:  0 item(s)

Home » » Cancer Research » Epigenetic Regulation » Eraser Enzymes » Sirtuins (SIRTs) » SIRT Inhibitors » 1652-10
Products and Applications 

SIRT1 Inhibitor, EX-527
A SIRT1 inhibitor

Catalog# Size Price    
1652-10 10 mg $165.00 Add to Cart

Product Image
Product Name: SIRT1 Inhibitor, EX-527

Alternate Name/Synonyms: EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Description: A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.

Peptide Sequence: N/A

Appearance: White solid

Formulation: N/A

CAS Number: 49843-98-3

Molecular Formula: C₁₃H₁₃ClN₂O

Molecular Weight: 248.71

Purity: ≥97% by HPLC

Solubility:DMSO (20 mg/ml)

Storage Temp.: +4°C

Shipping Conditions: RT

Handling: Protect from air and light

SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

InChi: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)


PubChem CID: 5113032

MDL Number: MFCD03009471

USAGE: For Research Use Only! Not For Use in Humans.

Product Toolbox

Product Support

Join Our Community
Check out our promotions and get free gifts with your purchase:

Subscribe for Updates
Subscribe to receive the latest news, promotions, and more.

Related Literature

Product Catalog

Download PDF


Diabetes & Obesity v.2

Download PDF

Stem Cell Research v.3

Download PDF

Metabolism Assay Kits

Download PDF

Protein Extraction

Download PDF


Download PDF


Download PDF


Download PDF


Download PDF


Download PDF


Download PDF