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Recombinant Murine Interleukin-27/p28 (IL-30)

A regulator of B- and T-lymphocyte's activities
Catalog #: 4187

Availability: In stock

SKU-Size Size Price Qty
4187-10 10 μg
$190.00
4187-1000 1 mg
$5,200.00

Product Details

Alternate Name Interleukin-30, IL-30, IL-27/p28, p28, Interleukin-27, Interleukin-27/p28, IL-27, Interleukin-27 subunit α, IL-27 subunit α, IL27-A, Il27, Il27a, IL-27p28.
Gene Symbol IL27
Gene ID 246779
Accession # Q8K3I6
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 10 mM NaP, pH 7.5
Molecular Weight 23.7 kDa
Purity by SDS-PAGE ≥97%
Purity by ≥97%
Endotoxin Level <0.01 ng/μg
Biological Activity Measured by dose-dependent inhibition of TGF-β & Il-6-induced IL-17A expression in mouse CD4 splenocytes. 50 ng/ml of mouse p28 is capable of inhibiting ≥25% of Il-17A expression in this assay.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-0.5 mg/ml. The solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

The p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines.  When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27.  p28 is thought to be a pro-inflammatory cytokine inducing immuno-modulatory effects, but the details of these effects are currently unclear and research is focused on delineating its specific biological functions.  Recombinant mouse p28 is a non-glycosylated protein, containing 207 amino acids, with a molecular weight of 23.7 kDa.


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