CRISPR-Cas9 Products

The bacterial adaptive immune system CRISPR (The Clustered Regularly Interspaced Short Palindromic Repeats)-Cas (CRISPR associated protein) has been used for the sequence-specific editing of mammalian genomes. The CRISPR system derived from Streptococcus pyogenes uses a Cas9 nuclease protein that complexes with a single guide RNA (sgRNA) containing a 20-nucleotide (nt) sequence for introducing site specific double-stranded breaks. Cells repair the break through one of two approaches, non-homologous end joining (NHEJ) or by homology-directed repair (HDR). Targeting the Cas9-sgRNA complex to DNA is specified by base pairing between the sgRNA and DNA as well as the presence of an adjacent NGG PAM (protospacer adjacent motif) sequence.
Thus, CRISPR-Cas9 system is the latest RNA-guided, endonuclease tool in genome editing which allows specific genomic disruption and replacement and provides an easy and quick way to modify the genome.

BioVision proudly announces the launch of highly pure and effective recombinant Streptococcus (S.) pyogenes, Cas9 proteins for genome editing using CRISPR-Cas9 technology. Additionally, Biovision offers small molecule compounds that can effectively enhance or decrease CRISPR-mediated homology-directed repair (HDR) efficiency or can reduce off-target CRISPR-mediated gene editing.

Key Features

• Highly Pure, Efficient, Ready-To-Use and a Wide Range of Gene Snipper™ Cas9 Proteins (WT or Mutants)
• Fast, Affordable, Reduced Cell Toxicity, Injection and Transfection Ready Cas9 Proteins
• Highly Specific Cas9 Monoclonal Antibody
• Small Molecule HDR Enhancers for enhancing CRISPR-mediated HDR efficiency
• Small Molecule HDR Blockers for decreasing CRISPR-mediated HDR efficiency

CRISPR-Cas9 Products Categories

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