Tumor Biomarkers

Screening for tumors based on proteins found in body fluids like plasma, urine, cells/ tissues is another approach to diagnose the presence of cancer and monitor its progression. These marker proteins are expressed at physiological levels in normal cells; however the levels increase by several folds in a cancer milieu. At this point there are ~20 different generic or specific tumor markers that are used for the diagnosis of cancer.

Our growing portfolio of research related products for specific tumor markers would enable researchers to understand the basic biology related to tumor biomarkers related to specific types of cancers

 

Tumor marker: Gene/ Protein Cancer type
ALK gene rearrangements  Non-small cell lung cancer and anaplastic large cell lymphoma
Alpha-fetoprotein (AFP)  Liver cancer and germ cell tumors
Beta-2-microglobulin (B2M)  Multiple myeloma, chronic lymphocytic leukemia, and some lymphomas
Beta-human chorionic gonadotropin (Beta-hCG)  Choriocarcinoma and testicular cancer
BCR-ABL fusion gene  Chronic myeloid leukemia
CA15-3/CA27.29  Breast cancer
CA19-9  Pancreatic cancer, gallbladder cancer, bile duct cancer, and gastric cancer
CA-125  Ovarian cancer
Calcitonin  Medullary thyroid cancer
Carcinoembryonic antigen (CEA)  Colorectal cancer and breast cancer
CD20  Non-Hodgkin lymphoma
Chromogranin A (CgA)  Neuroendocrine tumors
Estrogen receptor (ER)/progesterone receptor (PR)  Breast cancer
Fibrin/fibrinogen  Bladder cancer
HE4  Ovarian cancer
HER2/neu  Breast cancer, gastric cancer, and esophageal cancer
KIT  Gastrointestinal stromal tumor and mucosal melanoma
Lactate dehydrogenase  Germ cell tumors
Nuclear matrix protein 22  Bladder cancer
Prostate-specific antigen (PSA)  Prostate cancer
Thyroglobulin  Thyroid cancer
Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1)  Breast cancer

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Tumor Biomarkers

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