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Plumbagin

A potent histone acetyltransferase (HAT) inhibitor
Catalog #: 2290

Availability: In stock

SKU-Size Size Price Qty
2290-50 50 mg
$55.00
2290-250 250 mg
$195.00

Product Details

Alternate Name 5-Hydroxy-2-methyl-1,4-naphthalened­ione
Peptide Sequence No
Appearance Orange red solid
CAS # 481-42-5
Molecular Formula C₁₁H₈O₃
Molecular Weight 188.18
Purity ≥98%
Solubility DMSO (~20 mg/ml) or EtOH (~10 mg/ml)
SMILES CC1=CC(=O)C2=C(C1=O)C=CC=C2O
InChi InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
InChi Key VCMMXZQDRFWYSE-UHFFFAOYSA-N
PubChem CID 10205
MDL Number MFCD00001682
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.


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