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Home » » Epigenetics » Epigenetic Modulators (A-Z) » 2290-50
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Plumbagin
A potent histone acetyltransferase (HAT) inhibitor

Catalog# Size Price    
2290-50 50 mg $55.00 Add to Cart
2290-250250 mg$195.00Add to Cart

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Product Name: Plumbagin

Alternate Name/Synonyms: 5-Hydroxy-2-methyl-1,4-naphthalened­ione

Description: A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.

Peptide Sequence: No

Appearance: Orange red solid

Formulation: N/A

CAS Number: 481-42-5

Molecular Formula: C₁₁H₈O₃

Molecular Weight: 188.18

Purity: ≥98%

Solubility:DMSO (~20 mg/ml) or EtOH (~10 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from air and light

SMILES: CC1=CC(=O)C2=C(C1=O)C=CC=C2O

InChi: InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3

InChi Key: VCMMXZQDRFWYSE-UHFFFAOYSA-N

PubChem CID: 10205

MDL Number: MFCD00001682

USAGE: For Research Use Only! Not For Use in Humans.

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