Alternate Name/Synonyms: 5-Hydroxy-2-methyl-1,4-naphthalenedione
Description: A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
Peptide Sequence: No
Appearance: Orange red solid
CAS Number: 481-42-5
Molecular Formula: C₁₁H₈O₃
Molecular Weight: 188.18
Solubility:DMSO (~20 mg/ml) or EtOH (~10 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and light
InChi Key: VCMMXZQDRFWYSE-UHFFFAOYSA-N
PubChem CID: 10205
MDL Number: MFCD00001682
USAGE: For Research Use Only! Not For Use in Humans.