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PI3K-α Inhibitor

A potent and selective PI3Kα inhibitor
Catalog #: B1869

Availability: In stock

SKU-Size Size Price Qty
B1869-5 5 mg
$145.00
B1869-25 25 mg
$575.00

Product Details

Alternate Name 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
Appearance White solid
CAS # 371943-05-4
Molecular Formula C₁₆H₁₅N₃O₂S
Molecular Weight 313.4
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES C1COCCN1C2=NC(=NC3=C2SC=C3)C4=CC(=CC=C4)O
InChi InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2
InChi Key XXLAEKOWCYJOKK-UHFFFAOYSA-N
PubChem CID 9901372
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PI3Kα inhibitor is a potent and selective inhibitor of PI3Kα with IC₅₀ values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC₅₀ = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor inhibits A375 melanoma cell proliferation with an IC₅₀ value of 580 nM.
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