There's a better way to study p38 MAPK!
FOR IMMEDIATE RELEASE
- Aug. 15, 2016
-- BioVision introduces Phospho-p38 MAPK (Thr¹⁸⁰+Tyr¹⁸²) Translocation Assay Kit (Cell-Based) for research in the areas of inflammation, stress,autophagy, cell differentiation and many others. Mitogen-activated protein kinases (MAPKs) that are proline-directed serine and threonine protein kinases regulating numerous physiological and pathophysiological cell responses. The expression of p38 MAPKs is upregulated by inflammatory and stress stimuli and accumulating evidence suggests that p38 MAPKs play an important role in arthritis, and inflammation of the liver, kidney, brain, and lung which affect millions of people every year. Therefore, p38 is an important target in better understanding of inflammation and development of novel treatments. p38 MAPK is activated following phosphorylation at Thr180/Tyr182 by upstream MKK6 and MKK3 kinases. While in quiescent cells p38 localizes to both nucleus and cytosol, stress induced conformational changes within the active site result in selective translocation of activated-p38 into the nucleus. Thus, the selective nuclear accumulation of p38 could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets. BioVision's Phospho-p38 MAPK (Thr180+Tyr182) Translocation Assay Kit (Cell-Based) provides a valuable tool to detect the nuclear translocation of activated p38 in mammalian cells.
• Detection of nuclear translocation of phosphorylated-p38 in mammalian cells (human, rat, mouse)
• Screening effectors of p38 MAPK signaling pathway
• Detection of cellular stress, DNA damage, heat shock, and pro-inflammatory stimuli
• Easy-to-use, highly sensitive and specificity
• Validated with human J774 macrophages
• Include Thrombin as positive controls and DAPI as nucleus marker
For more information please visit: http://www.biovision.com/phospho-p38-mapk-thr-tyr-translo...
BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.