Meisoindigo

An anticancer agent
Catalog #: B1822

Availability: In stock

SKU-Size Size Price Qty
B1822-5 5 mg
$125.00
B1822-25 25 mg
$495.00

Product Details

Alternate Name (E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione; Methyl isoindigotin; N-Methylisoindigotin; Meisoindigo; Dian III
Appearance Crystalline solid
CAS # 97207-47-1 
Molecular Formula C₁₇H₁₂N₂O₂
Molecular Weight 276.29
Purity ≥98% by HPLC
Solubility DMSO
SMILES CN1C2=CC=CC=C2C(=C3C4=CC=CC=C4NC3=O)C1=O
InChi InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+
InChi Key QNOCRUSVMMAKSC-CCEZHUSRSA-N
PubChem CID 5479433
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of microtubules. It is also reported to have efficacy in acute myeloid leukemia. In the AML cell lines, HL-60, NB4 and U937, meisoindigo induces apoptosis in both caspase-dependent and -independent pathways.
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