Livin Antibody

Catalog #: 3338

Availability: In stock

$265.00

Product Details

Cat # +Size 3338-100
Size 100 µg
Antibody Target Livin
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid near the C-terminus of the long form of human Livin
Accession # Q96CA5
Gene ID 79444
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-Livin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunohistochemistry
Application & Usage Western blotting (2-6 µg/ml). However, the optimal dilution conditions should be determined individually. The antibody detects a band at ~33 kDa and a weaker band at 30 kDa, corresponding to Livin α and β. Raji cell lysate can be used as a positive contro
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Livin is a novel member in the IAP (inhibitor of apoptosis) protein family. Livin contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-α and Livin-β. Transfection of Livin protected cells from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin directly reacts with several caspases including Caspase-3, -7, and –9, and it inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c and ATP.
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