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Human Thioredoxin 1 (Trx1) Inhibitor Screening Kit (Fluorometric)

Simplest High-Throughput Assay To Screen Thioredoxin 1 Inhibitors
Catalog #: K535

Availability: In stock

$525.00

Product Details

Cat # +Size K535-100
Size 100 assays
Kit Summary • Detection method-Fluorescence (Ex/Em: 490/525 nm)
• Applications- Screening/studying/characterizing Thioredoxin 1 inhibitors
Detection Method Fluorescence (Ex/Em: 490/525 nm)
Species Reactivity Human
Applications Screening/studying/characterizing Thioredoxin 1 inhibitors
Features & Benefits • Rapid, simple & sensitive
• Convenient & HTS
• Includes inhibitor control
Kit Components • Trx1 Assay Buffer
• Trx1 Substrate (Lyophilized)
• DTT (1 M)
• Trx1 Enzyme (Lyophilized)
• Trx1 Inhibitor (50X)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The human Thioredoxin 1 (Trx1) is a key enzyme that protects cells from oxidative stress by reducing disulfides and methionine sulfoxide groups in oxidized proteins. It also regulates DNA repair and apoptosis. In mammals, Trx1 is necessary for growth and development. However, an aberrant elevated expression of Trx1 is known to promote lung, cervical, pancreatic, colorectal, and breast cancers. In BioVision’s Trx1 Inhibitor Screening Kit, Trx1 reduces quenched di-FITC-labeled oxidized glutathione (Trx1 substrate), to mono-FITC-labeled unquenched reduced glutathione. In the presence of a Trx1 inhibitor (control inhibitor included), the reaction is impeded resulting in lower or no signal. The assay is high-throughput adaptable and can be completed in less than 1 hr.


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