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Human Recombinant TXNRD1

A protein involved in redox signaling
SKU: 6330

Availability: In stock

$225.00

Details

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases

Product Details

Size 100 μg
SKU+Size 6330-100
Alternate Name Thioredoxin Reductase, GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR.
Gene Symbol TXNRD1
Gene ID 7296
Accession # Q16881
Source E. Coli
Appearance Liquid
Physical Form Description 0.5 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Molecular Weight 55.7 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Specific activity is 0.48-0.60 units/ml
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VR
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans