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Home » » Proteins and Enzymes » Proteins and Enzymes (A-Z) » 6330-100
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Human Recombinant TXNRD1
A protein involved in redox signaling

Catalog# Size Price    
6330-100 100 μg $315.00 Add to Cart

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Product Name: Human Recombinant TXNRD1

Alternate Name/Synonyms: Thioredoxin Reductase, GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR.

Gene Symbol: TXNRD1

Accession #: Q16881

Gene ID: 7296

Source: E. coli

Appearance: Liquid

Physical Form Description: 0.5 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.

Molecular Weight: 55.7 kDa

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: N/A

Biological Activity: Specific activity is 0.48-0.60 units/ml

Reconstitution Instructions: N/A

Storage Temp.: -80°C

Shipping: Gel pack

Background Information: Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGC

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.

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