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Human CellExp™ VEGF 165, Human Recombinant

A signaling protein involved in both vasculogenesis and angiogenesis
Catalog #: 6485

Availability: In stock

SKU-Size Size Price Qty
6485-10 10 µg
$230.00
6485-50 50 µg
$1,015.00

Product Details

Alternate Name Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF, MGC70609.
Gene Symbol VEGFA
Gene ID 7422
Accession # P15692
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Molecular Weight 45 kDa, homodimer, glycosylated
Purity by SDS-PAGE > 95%
Biological Activity EC50 is 600 ng/ml. The activity was determined by the dose-dependent stimulation of the proliferation of EA.hy926 human endothelial cells.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute at 0.2-0.3 mg/mL in distilled water is recommended.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Vascular Endothelial Growth Factor (VEGF) plays a key role in tumor angiogenesis in many cancers. The VEGF family consists of seven secretory glycoproteins: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and Placental Growth Factor (PlGF). The binding of VEGF and its receptors leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGFA/VEGF165 is a heparin-binding protein, which exists as a disulfide-linked homodimer. It induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Diseases associated with VEGFA/VEGF165 include microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. It is also related to the integrated Breast Cancer Pathway.


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