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Human CellExp™ PD-L1 /CD274 /B7-H1, human recombinant

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
SKU: 7429

Availability: In stock

SKU-Size Size Price Qty
7429-10 10 μg
$200.00
7429-50 50 μg
$615.00
7429-250 250 μg
$985.00
7429-1000 1000 μg
$1,970.00

Details

Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1). It has been identified as the ligand for PD1/PDCD1 (Cat. No. 7498) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1 is highly expressed in the heart, skeletal muscle, placenta, lung and weakly expressed in the thymus, spleen, kidney and liver. Through binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression, which makes it a promising therapeutic target for human autoimmune disease and malignant cancers. In tumor cells, PD-L1 is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.

Product Details

Alternate Name PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Gene Symbol CD274
Gene ID 29126
Accession # Q9NZQ7
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Molecular Weight This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 26.4 kDa. The predicted N-terminus is Phe 19. DTT-reduced Protein migrates as 35-40 kDa due to glycosylation.
Purity by SDS-PAGE ≥95%
Purity by ≥90%
Biological Activity Immobilized Human PD-L1, His Tag at 5 μg/mL (100 μL/well) can bind Human PD-1, His Tag with a linear range of 0.15-1.25 μg/mL.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.
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