Human CellExp™ PD-1 /PDCD1, human recombinant

Inhibits the T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
Part #: 7498

Availability: In stock

SKU-Size Size Price Qty
7498-10 10 μg
$200.00
7498-50 50 μg
$615.00
7498-250 250 μg
$1,845.00
7498-1000 1000 μg
$6,450.00

Product Details

Alternate Name PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
Gene Symbol PDCD1
Gene ID 5133
Accession # Q15116
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.5
Molecular Weight This protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 17.2 kDa. The predicted N-terminus is Leu 25. DTT-reduced Protein migrates as 25-40 kDa in SDS-PAGE due to glycosylation.
Purity by SDS-PAGE ≥95%
Biological Activity Immobilized Human PD-1, His Tag at 5μg/mL (100 μL/well) can bind Human PD-L1, His Tag with a linear range of 0.15-1.25 μg/mL
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Programmed cell death 1 (PD1) is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD1 functions as an inhibitory cell surface receptor which is involved in the regulation of T-cell function during immunity and tolerance. It is also a possible cell death inducer in association with other factors. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
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