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GNE 477

A potent and efficacious dual PI3K/mTOR inhibitor
Catalog #: B1657

Availability: In stock

SKU-Size Size Price Qty
B1657-5 5 mg
$125.00
B1657-25 25 mg
$475.00

Product Details

Alternate Name GNE 477; GNE477; GNE 477; 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
Appearance Solid
CAS # 1032754-81-6
Molecular Formula C₂₁H₂₈N₈O₃S₂
Molecular Weight 504.63
Purity >98%
Solubility DMSO
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C
InChi InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)
InChi Key AKKCGLXULFRAET-UHFFFAOYSA-N
PubChem CID 25207689
MDL Number MFCD20527726
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
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