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GMF-beta, human recombinant

A growth and differentiation factor in the vertebrate brain
Catalog #: 4880

Availability: In stock

SKU-Size Size Price Qty
4880-10 10 μg
$195.00
4880-1000 1 mg
$5,450.00

Product Details

Alternate Name Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF
Gene Symbol GMFB
Gene ID 2764
Accession # P60983
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized after dialysis against 20 mM PBS pH 7.4 and 130 mM NaCl.
Molecular Weight 17.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile H₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino Acid Sequence SESLVVCDVAEDLVEKLRKFR FRKETNNAAIIMKID KDKRLVVLDEELE GISPDELKELPER QPRFIVYSYKYQH DDGRVSYPLCFI FSSPVGCKPEQQ MMYAGSKNKLVQTA ELTKVFEIRNTED LTEEWLREKLGFFH
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve growth factor identified as a growth and differentiation factor in the vertebrate brain.Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression.GMF-beta enhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Cell- surface GMF-Beta acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells.GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.


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