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GHBP, human recombinant

A carrier protein for growth hormone
Catalog #: 4972

Availability: In stock

SKU-Size Size Price Qty
4972-10 10 μg
$95.00
4972-50 50 μg
$305.00
4972-1000 1 mg
$3,650.00

Product Details

Alternate Name GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein
Gene Symbol GHR
Gene ID 2690
Accession # P10912
Source E. coli
Appearance Lyophilized protein
Physical Form Description GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO₃.
Molecular Weight 30.3 kDa (19-256 aa + N-terminal poly-his tag)
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Reconstitution Instructions Reconstitute in sterile dH₂O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.


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