Alternate Names / Synonyms: GHR, GHBP, GH receptor, Somatotropin receptor
Gene Symbol: GHR
Accession #: P10912
Gene ID: 2690
Source: E. coli
Product Name: GHBP, human recombinant
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from a 4 mg/ml solution of the protein in 50 mM Tris, 100 mM NaCl, pH 8.0
Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: ≥95%
Endotoxin Level: <0.1 ng/μg
Biological Activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile water to ≥ 100 µg/ml.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 30.3 kDa. GHBP is purified by proprietary chromatographic techniques.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.