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Home » » Proteins and Enzymes » Proteins and Enzymes (A-Z) » 4972-50
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GHBP, human recombinant
A carrier protein for growth hormone

Catalog# Size Price    
4972-50 50 µg $229.00 Add to Cart
4972-10001 mg$3650.00Add to Cart
4972-1010 µg$95.00Add to Cart

Alternate Names / Synonyms: GHR, GHBP, GH receptor, Somatotropin receptor

Gene Symbol: GHR

Accession #: P10912

Gene ID: 2690

Source: E. coli

Product Name: GHBP, human recombinant

Appearance: Lyophilized protein

Physical Form Description: Lyophilized from a 4 mg/ml solution of the protein in 50 mM Tris, 100 mM NaCl, pH 8.0

Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)

Purity by SDS-PAGE: ≥95%

Purity by HPLC: ≥95%

Endotoxin Level: <0.1 ng/μg

Biological Activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile water to ≥ 100 µg/ml.

Storage Temp.: -20°C

Shipping: Gel pack

Background Information: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 30.3 kDa. GHBP is purified by proprietary chromatographic techniques.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans.

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