Alternate Names / Synonyms:
GHR, GHBP, GH receptor, Somatotropin receptor
Gene Symbol: GHR
Accession #: P10912
Gene ID: 2690
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO3.
Molecular Weight: 28.1 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Reconstitution Instructions: Reconstitute in sterile dH₂O not less than 100 ug/ml. This solution can then be diluted into other aqueous buffers
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.