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EED-226

A potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor
Catalog #: B1845

Availability: In stock

SKU-Size Size Price Qty
B1845-5 5 mg
$165.00
B1845-25 25 mg
$650.00

Product Details

Alternate Name N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine
Appearance White to off-white solid
CAS # 2083627-02-3 
Molecular Formula C₁₇H₁₅N₅O₃S
Molecular Weight 369.4
Purity ≥98% by HPLC
Solubility DMSO
SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4
InChi InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChi Key DYIRSNMPIZZNBK-UHFFFAOYSA-N
PubChem CID 123132228
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model.
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