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CRT0066101

A potent protein kinase D (PKD) inhibitor
Catalog #: B1847

Availability: In stock

SKU-Size Size Price Qty
B1847-1 1 mg
$95.00
B1847-5 5 mg
$375.00

Product Details

Alternate Name 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
Appearance Yellow solid
CAS # 1883545-60-5
Molecular Formula C₁₈H₂₂N₆O.2HCl
Molecular Weight 411.33
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCC(CNC1=CC=NC(=C2C=C(C=CC2=O)C3=CN(N=C3)C)N1)N.Cl.Cl
InChi InChI=1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,21,23H,3,10,19H2,1-2H3;2*1H/b18-15+;;/t14-;;/m1../s1
InChi Key YABREXUEJVISSM-ILDIYEGTSA-N
PubChem CID 126970672
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CRT0066101 is a potent inhibitor of protein kinase D (PKD). It inhibits all PKD isoforms (IC₅₀ values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). It displays selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src.
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