While histone acetylation provides increased accessibility of transcription factors to DNA, the deacetylation of histones is associated with transcriptional silencing. Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants. Oxidative stress and the associated damage to cellular lipids, proteins and DNA can contribute to a decline in cellular function, leading to a number of human pathologies. BioVision offers various convenient kits for analyzing transcriptional regulation, DNA damage, oxidative stress, energy transforming and redox state, and more are coming in the pipeline. |