BVT948

A noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases
Catalog #: B1810

Availability: In stock

SKU-Size Size Price Qty
B1810-1 1 mg
$85.00
B1810-5 5 mg
$335.00

Product Details

Alternate Name 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Appearance Red solid
CAS # 39674-97-0
Molecular Formula C₁₄H₁₁NO₃
Molecular Weight 241.25
Purity ≥98%
Solubility DMSO (>10 mg/ml)
SMILES CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C
InChi InChI=1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6H,1-2H3,(H,15,18)
InChi Key LLPBUXODFQZPFH-UHFFFAOYSA-N
PubChem CID 6604934
MDL Number MFCD00616487
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC₅₀s = 0.09-1.7 µM). displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo.
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