BAY 43-9006

A VEGFR and PDGFR kinase inhibitor
Catalog #: 1594

Availability: In stock

SKU-Size Size Price Qty
1594-25 25 mg
1594-100 100 mg

Product Details

Appearance Off-white solid
CAS # 475207-59-1
Molecular Formula C₂₁H₁₆ClF₃N₄O₃.C₇H₈O₃S
Molecular Weight 637.03
Purity ≥99%
Solubility DMSO (200 mg/ml)
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChi InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
PubChem CID 406563
MDL Number MFCD08235032
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BAY 43-9006 is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-β and their associated signaling cascades.
Lee et al., Arabidopsis Putative MAP Kinase Kinase Kinases Raf10 and Raf11 are Positive Regulators of Seed Dormancy and ABA Response. Plant Cell Physiol., Jan 2015; 56: 84 - 97.
Chen et al., Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo.Clin. Cancer Res., Mar 2014; 20: 1274 - 1287.
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