BAR-501

selective GPBAR1 agonist devoid of any FXR agonistic activity
Part #: B1591

Availability: In stock

SKU-Size Size Price Qty
B1591-5 5 mg
$135.00
B1591-25 25 mg
$535.00

Product Details

Alternate Name  (3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
Appearance Crystalline solid
CAS # 1632118-69-4 
Molecular Formula C₂₆H₄₆O₃ 
Molecular Weight 406.65
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCCO)C)C)O
InChi InChI=1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1
InChi Key DQBAHTQWQZRMFH-CRPAWOMZSA-N
MDL Number 101886302
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC₅₀ of 1 μM. Exposure of GLUTAg cells to BAR501 (10 μM) increases the expression of GLP-1 mRNA by 2.5 folds.
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