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Afuresertib hydrochloride

A potent and selective Akt inhibitor
Catalog #: B1848

Availability: In stock

SKU-Size Size Price Qty
B1848-5 5 mg
$115.00
B1848-25 25 mg
$455.00

Product Details

Alternate Name N-​[(1S)​-​2-​amino-​1-​[(3-​fluorophenyl)​methyl]​ethyl]​-​5-​chloro-​4-​(4-​chloro-​1-​methyl-​1H-​pyrazol-​5-​yl)​-2-​thiophenecarboxamide, monohydrochloride​
Appearance Crystalline solid
CAS # 1047645-82-8
Molecular Formula C₁₈H₁₇Cl₂FN₄OS • HCl
Molecular Weight 463.8
Purity ≥98% by HPLC
Solubility DMSO >30 mg/ml)
SMILES CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
InChi InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1
InChi Key YFQJOPFTGMHYNV-YDALLXLXSA-N
PubChem CID 46843056
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Afuresertib is a potent and selective Akt inhibitor with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. 


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